David Huang, Eric A. Swanson, Charles P. Lin, Joel S. Schuman, William G. Stinson, Watten Chang, Michael R. Hee, Thomas Flotte, Kenton Gregory, Carmen A. Puliafito, James G. Fujimoto
A technique called optical coherence tomography(OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of oprical scattering from internal tissue microstructures in a wat that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micremeters and can detect reflexted signals as smass as ~10-10 of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.
refernece : Science, vol. 254, no. 5035, pp. 1178–1181, 1991.